Publications

Yap C, Hoogeland ME, Li S, Bakker I, Yalcin E, Ottenhoff R, Clemente-Olivo MP, Kooijman S, Morcos Y, Sengle G, de Waard V. A high-fat diet does not exacerbate aortic pathology and enhances metabolic function in Marfan syndrome Fbn1(C1041G/+) mice.Biochim Biophys Acta Mol Basis Dis. March 2026;1872(3):168107. doi: 10.1016/j.bbadis.2025.168107. PMID: 41232577.

von Stein P, von Stein J, Schindhelm F, Rudolph F, Sagmeister P, Haurand JM, Jobst J, Gröger M, Stolz L, Schulz C, Mues CA, Mustafa D, Hoerbrand IA, Sugiura A, Wolff C, Lurz P, Jahn P, Ascione G, Guthoff H, Baldus S, Rottbauer W, Gerçek M, Pfister R, Rassaf T, Weber M, Konstandin M, Möllmann H, Schofer N, Hausleiter J, Kessler M, Unsöld B, Horn P, Kister T, Rudolph V, Mahabadi AA, Granada JF, Mauri V. Small Mitral Valve Orifice Area in Mitral Valve Transcatheter Edge-to-Edge Repair: The REPAIR Study.JACC Adv. June 25, 2026;103014. doi: 10.1016/j.jacadv.2026.103014. PMID: 42358112.

von Stein P, Schindhelm F, Rudolph F, Sagmeister P, Haurand JM, Jobst J, Gröger M, Stolz L, Schulz C, Mues CA, Mustafa D, Hoerbrand IA, Sugiura A, Wolff C, Lurz P, von Stein J, Ascione G, Guthoff H, Baldus S, Rottbauer W, Gerçek M, Pfister R, Rassaf T, Weber M, Konstandin M, Möllmann H, Schofer N, Hausleiter J, Kessler M, Unsöld B, Horn P, Kister T, Rudolph V, Mahabadi AA, Granada JF, Mauri V. Sex-Specific Outcomes in Patients Undergoing Transcatheter Edge-to-Edge Mitral Valve Repair: The REPAIR Study.JACC Adv. June 2026;5(6 Pt 1):102782. doi: 10.1016/j.jacadv.2026.102782. PMID: 42132712; PMCID: PMC13309300.

Thériault S, Holdcraft JA, Sharipova D, Faucherre A, Debiec RM, Peloso GM, Al-Kassou B, Aranki S, Ashikhmina Swan E, Ballotta A, Bellino M, Björck HM, Boureau AS, Braund PS, Corriveau F, Dagenais F, Folkersen L, Forte A, Francke MD, Frigiola A, Gorbatov S, Guo D, Habchi KM, Heydarpour M, Isselbacher EM, Jopling C, Laporte F, Le Scouarnec S, Li Z, Lichtner P, Maj C, Manikpurage HD, Nelson CP, Nguyen TB, Norris RA, Ong CS, Pibarot P, Roychowdhury T, Sarubbi B, Simonet F, Sundt T, Surakka I, Tessler I, Willer CJ, Wittmann S, Yang B, Berezovets I, Doppler SA, Dreßen M, Knoll K, Puehler T, Schunkert H, Avierinos JF, Bissell MM, Bolger AP, Bossé Y, Bossone E, Brion M, Citro R, de Vincentiis C, Deeb GM, Della Corte A, Dina C, Durst R, Ensminger S, Eriksson P, Evangelista A, Franco-Cereceda A, Gilon D, Giusti B, Hetherington SL, Huggins GS, Krane M, Le Tourneau T, Limongelli G, Mathieu P, Messika-Zeitoun D, Michelena HI, Milewicz D, Muehlschlegel JD, Murdock DR, Nickenig G, Nistri S, Nöthen MM, Pluchinotta F, Prakash SK, Samani NJ, Schott JJ, Webb TR, Zaffran S, Abdelilah-Seyfried S, Eagle K, Schumacher J, Trenkwalder T, Body SC. Genome- and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.Circulation. April 7, 2026;153(14):1060–76. doi: 10.1161/CIRCULATIONAHA.125.074752. PMID: 41645906; PMCID: PMC13001617.

Small AM, Yang TY, Itoh S, Thériault S, Dufresne L, Kurosawa R, Komuro I, Matsuda K, Vy HMT, Farber-Eger EH, Shaffer LL, Boulier KM, Corey KM, Ramaker ME, Laporte F, Schott JJ, Le Scouarnec S, Singh SA, Sonawane AR, Smith HA, Rafaels N, Ghouse J, Raja AA, Ostrowski SR, Sørensen E, Mikkelsen C, Pedersen OB, Erikstrup C, Ullum H, Sveinbjornsson G, Gudbjartsson DF, Abner E, Lee J, Ganna A, Nowak-Göttl U, Finer S, Schumacher J, Maj C, Al-Kassou B, Nickenig G, Trenkwalder T, Dreβen M, Krane M, Nöthen MM, Moksnes MR, Brumpton BM, Knight S, Knowlton KU, Nadauld L, Debiec R, Musameh MD, Braund PS, Nelson CP, Czuba T, Melander O, Selvaraj MS, Koyama S, Bhukar R, Ruan Y, Ljungberg J, Damrauer SM, Levin MG, Franke A, Berger K, Ruff CT, Melloni GEM, Kamanu FK, Ito K, Do R, Loos RJF, Schunkert H, Wells QS, Shah SH, Le Tourneau T, Messika-Zeitoun D, Gignoux C, Bundgaard H, Larsson SC, Michaëlsson K, Holm H, Helgadottir A, Esko T, van Heel DA, Mathieu P, Samani NJ, Smith JG, Söderberg S, Rader DJ, Marston NA, Sabatine MS, Pasaniuc B, Cho K, Wilson PWF, O’Donnell CJ, Stefansson K, Bossé Y, Aikawa E, Engert JC, Peloso GM, Natarajan P, Thanassoulis G. Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.Nat Genet. January 2026;58(1):57–66. doi: 10.1038/s41588-025-02417-6. PMID: 41419686; PMCID: PMC12807872.

Schelemei P, Picard FSR, Park Y, Wollnitzke P, Nemade H, Lechner SK, Mehrkens D, Arkenberg P, Köbele AC, Wrobel J, Martinez Lagunas K, Wagner E, Guthoff H, Hof A, Cummings K, Al Zaidi M, Zimmer S, Roy J, Lindquist Liljeqvist M, Wolf D, Riffelmacher T, Ibing W, Wagenhäuser MU, Schelzig H, Levkau B, Flögel U, Gerdes N, Karimpour M, Hillmer AM, Sengle G, Megens RTA, Weber C, Orecchioni M, Baldus S, Mollenhauer M, Winkels H. Olfr2 Promotes Recruitment of Monocytes via CX3CR1 in Abdominal Aortic Aneurysm.Circ Res. January 30, 2026;138(3). doi: 10.1161/CIRCRESAHA.125.326591. PMID: 41473953.

Nemade H, Mehrkens D, Lottermoser HS, Yilmaz ZE, Mader J, Schelemei P, Picard FR, Geißen S, Schwab GF, Hoyer FF, Guthoff H, Hof A, Nettersheim FS, Sachinidis A, Gerdes N, Sengle G, Winkels H, Baldus S, Pasparakis M, Mollenhauer M, Adam M. Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis.Cell Death Dis. February 11, 2026;17(1):217. doi: 10.1038/s41419-026-08427-4. PMID: 41672970; PMCID: PMC12920694.

Mehrkens D, Dohr J, Nettersheim FS, Ballmann F, Bastigkeit J, Brückner A, Geissen S, De Vore L, Fitsch C, Diekmann C, de la Fuente-Alonso A, Schelemei P, Picard FR, Kochen M, Arkenberg P, Rappenecker A, Ahdab M, Nemade H, Narayan S, Braumann S, Kreuzberg W, Hof A, Guthoff H, Mensah BQ, Lechner S, Guala A, Evangelista A, Teixido-Tura G, Nistal JF, Campanero MR, Kaemmerer H, Wolf Z, Holdenrieder S, Groenink M, van Andel M, Mieremet A, Pfeiler S, Gerdes N, Flögel U, Zimmermann LM, Sengle G, Eich ML, Schömig-Markiefka B, Adam M, Fleischmann BK, Wenzel D, Redondo JM, de Waard V, Klinke A, Baldus S, Mollenhauer M, Winkels H. Myeloperoxidase aggravates thoracic aortic aneurysm formation in Marfan syndrome.Cardiovasc Res. March 16, 2026;122(2):230–44. doi: 10.1093/cvr/cvaf248. PMID: 41403006.

Guthoff H, Abdel-Waha M, Kim WK, Wienemann H, Shamekhi J, Eckel C, von der Heide I, Veulemans V, Landt M, Schewel J, Van Mieghem NM, Adrichem R, Toggweiler S, Rheude T, Macherey-Meyer S, Bleiziffer S, Al-Kassou B, Nienaber S, Wrobel J, Richter I, Möllmann H, Renker M, Charitos E, Schofer N, Zeus T, Schmidt T, von Stein P, Thiele H, Witberg G, Adam M, Baldus S, Rudolph TK, Mauri V. Sex differences in hemodynamics and outcomes after transcatheter aortic valve replacement.Clin Res Cardiol. July 2026;115(7):1207–17. doi: 10.1007/s00392-025-02794-2. PMID: 41264012; PMCID: PMC13249733.

Yogathasan V, Wischmann P, Solga I, Jäger L, Becher S, Cortese-Krott MM, Gerdes N, Kelm M, Jung C, Chennupati R. Divergent roles of endothelial and red blood cell nitric oxide synthase in regulating cardiovascular function during anemia.Nitric Oxide. December 2025;159:1–10. doi: 10.1016/j.niox.2025.08.004. PMID: 40865872.

Wenzl FA, Wang P, Kahles F, Beck KR, Giannitsis E, Obeid S, Bruno F, Li XS, Nanchen D, Liberale L, Smolle MA, Schweiger V, Klingenberg R, Manka R, Stähli BE, Templin C, König M, Yuan J, Yildirim M, Lehrke M, von Eckardstein A, Marx N, Mach F, Räber L, Katus HA, Steinhagen-Thiessen E, Demuth I, Deanfield J, Libby P, Hazen SL, Haghikia A, Landmesser U, Bäckhed F, Lüscher TF. Gut microbiota-derived imidazole propionate predicts cardiometabolic risk in patients with coronary artery disease.Eur Heart J. August 30, 2025;ehaf661. doi: 10.1093/eurheartj/ehaf661. PMID: 40884168.

von Stein P, Stolz L, Haurand JM, Gröger M, Rudolph F, Mustafa D, Jobst J, Mues CA, Mahabadi AA, Hoerbrand IA, Schulz C, Sugiura A, von Stein J, Iliadis C, Lurz P, Gerçek M, Horn P, Kessler M, Ascione G, Rassaf T, Weber M, Schofer N, Konstandin M, Schindhelm F, Möllmann H, Unsöld B, Guthoff H, Baldus S, Rottbauer W, Rudolph V, Granada JF, Hausleiter J, Pfister R, Mauri V. Transcatheter Edge-to-Edge Repair for Atrial and Ventricular Secondary Mitral Regurgitation: Insights From the REPAIR Study.JACC Cardiovasc Interv. August 25, 2025;18(16):2020–32. doi: 10.1016/j.jcin.2025.05.031. PMID: 40560108.

von Stein P, Stolz L, Haurand JM, Gröger M, Rudolph F, Mustafa D, Jobst J, Mues CA, Mahabadi AA, Hoerbrand IA, Schulz C, Sugiura A, Ruf T, Lurz P, Gerçek M, Horn P, Kessler M, Rassaf T, Weber M, Kister T, Schofer N, Konstandin M, Schindhelm F, Möllmann H, Unsöld B, Baldus S, Rottbauer W, Rudolph V, Hausleiter J, Pfister R, Mauri V. Outcomes and Impact of Device Iterations in Transcatheter Edge-to-Edge Mitral Valve Repair: The REPAIR Study.JACC Cardiovasc Interv. March 10, 2025;18(5):573–86. doi: 10.1016/j.jcin.2024.11.016. PMID: 39745410.

von Stein P, Hausleiter J, Horn P, Kessler M, Rudolph V, Unsöld B, Möllmann H, Mahabadi AA, Kister T, Mauri V. Transcatheter Edge-to-Edge Repair in Secondary Mitral Regurgitation: Mind the Gap Between Guidelines and COAPT Criteria.JACC Cardiovasc Interv. December 8, 2025;18(23):2967–9. doi: 10.1016/j.jcin.2025.09.036. PMID: 41137833.

by Stein P, Hausleiter J, Horn P, Kessler M, Rudolph V, Unsöld B, Lurz P, Weber M, Schofer N, Konstandin MH, Granada JF, Möllmann H, Mahabadi AA, Kister T, Mauri V. Pulmonary Artery Systolic Pressure Trajectories After Transcatheter Edge-to-Edge Repair in Atrial and Ventricular Secondary Mitral Regurgitation.Circ Cardiovasc Interv. December 2025;18(12). doi: 10.1161/CIRCINTERVENTIONS.125.016067. PMID: 41241823.

Trenkwalder T, Maj C, Al-Kassou B, Debiec R, Doppler SA, Musameh MD, Nelson CP, Dasmeh P, Grover S, Knoll K, Naamanka J, Mordi IR, Braund PS, Dreßen M, Lahm H, Wirth F, Baldus S, Kelm M, von Scheidt M, Krefting J, Ellinghaus D, Small AM, Peloso GM, Natarajan P, Thanassoulis G, Engert JC, Dufresne L, Franke A, Görg S, Laudes M, Nowak-Göttl U, Vaht M, Metspalu A, Stoll M, Berger K, Pellegrini C, Kastrati A, Hengstenberg C, Lang CC, Kessler T, Hovatta I, Nickenig G, Nöthen MM, Krane M, Schunkert H, Samani NJ, Schumacher J, Kals M, Reigo A, Teder-Laving M, Gehlen J, Webb TR, Giel AS, Koebbe LL, Feirer N, Billmann M, Srinivasan S, Zimmer S, Palmer CNA, Li L, Yang C, Borisov O, Adam M, Veulemans V, Joner M, Xhepa E. Distinct Genetic Risk Profile in Aortic Stenosis Compared With Coronary Artery Disease.JAMA Cardiol. February 1, 2025;10(2):145–54. doi: 10.1001/jamacardio.2024.3738. PMID: 39504041; PMCID: PMC11541746.

Stei M, Arkenberg P, Uebing T, Mazrekaj A, Mulorz J, Mehrkens D, Ahdab M, Barnowski P, Sengle G, Adam M, Lohner V, Hoerr V, Nahardani A, Schubert-Quecke C, Mewes B, Lindemeyer J, Grüll H, Busch A, Zimmer S, Winkels H, Schelzig H, Kelm M, Nickenig G, Baldus S, Wagenhäuser MU, Mollenhauer M. An improved porcine model of infrarenal abdominal aortic aneurysm.Sci Rep. December 17, 2025;15(1):44059. doi: 10.1038/s41598-025-31690-y. PMID: 41408131; PMCID: PMC12714784.

Spanou CES, Yang C, Godwin ARF, Morosky S, Anbalagan A, Lütke S, Mörgelin M, Marcous F, Aziz U, Wohl AP, Jabeen I, Koch M, Jowitt TA, Roman BL, Tarakanova A, Baldock C, Sengle G. Prodomain processing controls BMP-10 bioactivity and targeting to fibrillin-1 in its latent conformation.FASEB J. February 15, 2025;39(3). doi: 10.1096/fj.202401694R. PMID: 39921464; PMCID: PMC11806408.

Solga I, Şahin A, Yogathasan V, Hofer L, Celik FG, El Rai A, Hosen MR, Wischmann P, Becher S, Polzin A, Gerdes N, Jung C, Kelm M, Chennupati R. Acute blood loss anemia aggravates endothelial dysfunction after acute myocardial infarction.Front Cardiovasc Med. 2025;12:1635293. doi: 10.3389/fcvm.2025.1635293. PMID: 41158731; PMCID: PMC12554764.

Rudolph F, Geyer M, Baldus S, De Luca VM, Doenst T, Pfister R, Gummert J, Kessler M, Boekstegers P, Lubos E, Schröder J, Thiele H, Walther T, Kelm M, Hausleiter J, Eitel I, Fischer-Rasokat U, Bufe A, Schmeisser A, Ince H, Lurz P, von Bardeleben RS, Hagl C, Noack T, Reith S, Beucher H, Reichenspurner H, Rottbauer W, Schulze PC, Müller W, Frank J, Michalik C, Hellmich M, Wahlers T, Rudolph V, Iliadis C. Transcatheter Repair Versus Surgery for Atrial Versus Ventricular Functional Mitral Regurgitation: A Post Hoc Analysis of the MATTERHORN Trial.Circulation. February 11, 2025;151(6):418–20. doi: 10.1161/CIRCULATIONAHA.124.072648. PMID: 39475706.

Mustafa D, von Stein J, Stolz L, Haurand JM, Gröger M, Rudolph F, Jobst J, Mues CA, Mahabadi AA, Hoerbrand IA, Schulz C, Sugiura A, Lurz P, Kister T, Sagmeister P, Wolff C, Gerçek M, Horn P, Kessler M, Ascione G, Rassaf T, Weber M, Schofer N, Konstandin MH, Schindhelm F, Möllmann H, Unsöld B, Guthoff H, Baldus S, Rottbauer W, Rudolph V, Granada JF, Hausleiter J, Pfister R, Mauri V, von Stein P. Relation of Residual Mitral Regurgitation and Gradient Following Transcatheter Edge-to-Edge Mitral Valve Repair.Circ Cardiovasc Interv. November 2025;18(11). doi: 10.1161/CIRCINTERVENTIONS.125.015845. PMID: 41150378.

Mourikis P, Benkhoff M, Wildeis L, Barcik M, Helten C, Coman C, Solari FA, Krahn D, Dannenberg L, Ahlbrecht S, Zikeli D, Utz A, Trojovsky K, Richter H, Al Kassis G, M’Pembele R, Zako S, Huckenbeck T, Bauer S, Schmitz D, Pfeiler S, Gerdes N, Dücker C, Pircher J, Zhe Z, Thienel M, Ul Ain Q, Keul P, Kirkby N, Sohn D, Budach W, Hohlfeld T, Schrör K, Levkau B, Zeus T, Verhelst SHL, Ahrends R, Sickmann A, Mitchell J, Mora S, Manson JE, Bhatt DL, Landmesser U, Massberg S, Kelm M, Petzold T, Polzin A. Icosapent ethyl reduces arterial thrombosis by inhibiting cyclooxygenase-1-induced platelet reactivity.Sci Transl Med. May 21, 2025;17(799). doi: 10.1126/scitranslmed.ado0610. PMID: 40397711.

Moellmann J, Glandien K, Klinkhammer BM, Wollenhaupt J, Noels H, Jankowski J, Lebherz C, Boor P, Lehrke M, Marx N. Development of a Mouse Model of Uremic Cardiomyopathy: Investigating the Impact of Chronic Kidney Disease on Cardiac Function and Signaling Pathways.FASEB J. May 31, 2025;39(10). doi: 10.1096/fj.202500281R. PMID: 40386987; PMCID: PMC12086955.

Marx-Schütt K, Cherney DZI, Jankowski J, Matsushita K, Nardone M, Marx N. Cardiovascular disease in chronic kidney disease.Eur Heart J. June 16, 2025;46(23):2148–60. doi: 10.1093/eurheartj/ehaf167. PMID: 40196891; PMCID: PMC12167664.

Kurt B, Reugels M, Schneider KM, Spiesshoefer J, Milzi A, Gombert A, Fordyce CB, Wenzl FA, Pagidipati NJ, Rocha V, Fudim M, Sharma A, Lehrke M, Shimokawa H, Liuzzo G, Tokgozoglu L, Crea F, Lüscher TF, Libby P, Ridker PM, Marx N, Schneider CV, Kahles F. C-reactive protein and cardiovascular risk in the general population.Eur Heart J. December 11, 2025;47(15):1799–810. doi: 10.1093/eurheartj/ehaf937. PMID: 41378999; PMCID: PMC13101082.

Kurt B, Rau M, Hartmann O, Bergmann A, Reugels M, Just S, Wenzl FA, Moellmann J, Spießhöfer J, Milzi A, Kneizeh K, Thiele K, Hohl M, Selejan SR, van der Vorst EPC, Dahl E, Schröder J, Lüscher TF, Marx N, Lehrke M, Kahles F. Adjustment of the SMART risk score using bioactive adrenomedullin enables a more accurate prediction of mortality in patients with ASCVD.Atherosclerosis. July 2025;406:120220. doi: 10.1016/j.atherosclerosis.2025.120220. PMID: 40449381.

Jung C, Lang A, Duse DA, Bruno RR, Pöss J, Wolff G, Ceglarek U, Zeymer U, Fuernau G, Zweck E, Desch S, Freund A, Isermann B, Pfeiler S, Wernly B, Kelm M, Thiele H, Gerdes N. Plasma Proteome Analysis Identifies Vascular Endothelial Growth Factor Receptor 1 as a Prognostic Biomarker in Cardiogenic Shock.Circ Heart Fail. December 2025;18(12). doi: 10.1161/CIRCHEARTFAILURE.125.012890. PMID: 41031405.

Humbert M, McLaughlin VV, Badesch DB, Ghofrani HA, Gibbs JSR, Gomberg-Maitland M, Preston IR, Souza R, Waxman AB, Moles VM, Savale L, Vizza CD, Rosenkranz S, Shi Y, Miller B, Mackenzie HS, Kim SS, Loureiro MJ, Patel MJ, Koglin J, Cornell AG, Hoeper MM. Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death.N Engl J Med. May 29, 2025;392(20):1987–2000. doi: 10.1056/NEJMoa2415160. PMID: 40167274.

Heyn J, Gorgels A, Hense N, Gombert A, Buhl EM, Stark L, Vondenhoff S, Simon J, Noels H, Marx N, Goettsch C. GRP75 inhibition attenuates arterial calcification.Atherosclerosis. October 2025;409:119243. doi: 10.1016/j.atherosclerosis.2025.119243. PMID: 40410081.

Guthoff H, Abdel-Wahab M, Kim WK, Shamekhi J, Möllmann H, Van Mieghem NM, Toggweiler S, Rheude T, Zeus T, Rudolph TK, Mauri V. Clinical Impact of Balloon-Expandable vs. Self-Expanding TAVR in Small Aortic Annuli.JACC Cardiovasc Interv. June 23, 2025;18(12):1611–3. doi: 10.1016/j.jcin.2025.03.020. PMID: 40338787.

de Souza RB, Cassiano LL, Barnowski P, Ventura S, Turato WM, Nascimento SCR, Mignanelli GL, Caldeira W, da Fonseca Martins AMCRP, de Carvalho Luposeli F, Laurindo FRM, Reinhardt DP, Sengle G, Koh IHJ, Meek KM, Lewis PN. Exploring ECM alterations in the thoracic aorta in Marfan syndrome: insights into aortic wall structure.Sci Rep. July 22, 2025;15(1):26665. doi: 10.1038/s41598-025-09665-w. PMID: 40695874; PMCID: PMC12284111.

Casagrande V, Panarello L, Lepri A, Quatrana A, Internò C, Antonetti L, Bonanno E, Cicalini I, Pieragostino D, Gorgels A, De Laurenzi V, Goettsch C, Cardellini M, Federici M, Menghini R. Effect of in vivo administration of 3-hydroxyisobutyrate on cardiometabolic disease in an ApoE-/- mouse model.Pharmacol Res. October 2025;220:107943. doi: 10.1016/j.phrs.2025.107943. PMID: 40930330.

Bruenger CMH, Oeffner F, Koebbe LL, Zimmer S, Veulemans V, Adam M, Bigge J, Heilmann-Heimbach S, Kelm M, Baldus S, Nöthen MM, Nickenig G, Maj C, Al-Kassou B, Schumacher J. Implications of monogenic bicuspid aortic valve (BAV) forms among sporadic BAV patients.Eur J Hum Genet. September 2025;33(9):1203–6. doi: 10.1038/s41431-025-01909-7. PMID: 40646242; PMCID: PMC12402177.

Berger M, Reugels M, Heinzmann A, Lysaja K, Rizk M, Kern JS, Wolf M, Wolfart S, Jankowski V, Jankowski J, Marx N, Marx-Schütt K. Association of Complement Factor D with Cardiovascular Mortality and Clot Lysis in CKD.J Am Soc Nephrol. December 1, 2025;36(12):2469–72. doi: 10.1681/ASN.0000000870. PMID: 40844849; PMCID: PMC12677817.

Benkhoff M, Barcik M, Mourikis P, Dahlmanns J, Kahmann P, Wollnitzke P, Hering M, Huckenbeck T, Hoppe J, Semleit N, Deister-Jonas J, Zako S, Seel J, Coman C, Barth M, Cramer M, Helten C, Wildeis L, Hu H, Al-Kassis G, Metzen D, Hesse J, Weber J, Dannenberg L, Akhyari P, Lichtenberg A, Quast C, Gerdes N, Zeus T, Borst O, Kelm M, Petzold T, Ahrends R, Levkau B, Polzin A. Targeting Sphingosine-1-Phosphate Signaling to Prevent the Progression of Aortic Valve Disease.Circulation. January 28, 2025;151(4):333–47. doi: 10.1161/CIRCULATIONAHA.123.067270. PMID: 39429140.

Zierden M, Berghausen EM, Gnatzy-Feik L, Millarg C, Picard FSR, Kiljan M, Geißen S, Polykratis A, Zimmermann L, Nies RJ, Pasparakis M, Baldus S, Valasarajan C, Pullamsetti SS, Winkels H, Vantler M, Rosenkranz S. HematopoieticPI3Kδ deficiency aggravates murine atherosclerosis through impairment of Tregs.JCI Insight. November 22, 2024;9(22). doi: 10.1172/jci.insight.155626. PMID: 39378110; PMCID: PMC11601942.

von Stein P, Wienemann H, von Stein J, Sugiura A, Tanaka T, Kavsur R, Öztürk C, Weber M, Haurand JM, Horn P, Kister T, Mahabadi AA, Boeder N, Ruf T, Gerçek M, Mues C, Grothusen C, Novotny J, Weckbach L, Guthoff H, Rudolph F, Polzin A, Baldus S, Rassaf T, Thiele H, Möllmann H, Kelm M, Rudolph V, von Bardeleben RS, Nef H, Luedike P, Lurz P, Hausleiter J, Pfister R, Mauri V. Early Outcomes of Two Large Mitral Valve Transcatheter Edge-to-Edge Repair Devices—A Propensity Score-Matched Multicenter Comparison.J Clin Med. July 17, 2024;13(14). doi: 10.3390/jcm13144187. PMID: 39064227; PMCID: PMC11278441.

Schelemei P, Wagner E, Picard FSR, Winkels H. Macrophage mediators and mechanisms in cardiovascular disease.FASEB J. February 2024;38(2). doi: 10.1096/fj.202302001R. PMID: 38275140.

Quast C, Bönner F, Polzin A, Veulemans V, Chennupati R, Gyamfi Poku I, Pfeiler S, Kramser N, Nankinova M, Staub N, Zweck E, Jokiel J, Keyser F, Hoffe J, Witkowski S, Becker K, Leuders P, Zako S, Erkens R, Jung C, Flögel U, Wang T, Neidlin M, Steinseifer U, Niepmann ST, Zimmer S, Gerdes N, Cortese-Krott MM, Feelisch M, Zeus T, Kelm M. Aortic Valve Stenosis Causes Accumulation of Extracellular Hemoglobin and Systemic Endothelial Dysfunction.Circulation. September 17, 2024;150(12):952–65. doi: 10.1161/CIRCULATIONAHA.123.064747. PMID: 38836358.

Moellmann J, Krueger K, Wong DWL, Klinkhammer BM, Buhl EM, Dehairs J, Swinnen JV, Noels H, Jankowski J, Lebherz C, Boor P, Marx N, Lehrke M. 2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression, and impaired renal mitochondrial function.Biochim Biophys Acta Mol Basis Dis. January 2024;1870(1):166825. doi: 10.1016/j.bbadis.2023.166825. PMID: 37536502.

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