Publikationen

Yap C, Hoogeland ME, Li S, Bakker I, Yalcin E, Ottenhoff R, Clemente-Olivo MP, Kooijman S, Morcos Y, Sengle G, de Waard V. High-fat diet does not exacerbate aortic pathology and enhances metabolic function in Marfan syndrome Fbn1(C1041G/+) mice.Biochim Biophys Acta Mol Basis Dis. März 2026;1872(3):168107. doi: 10.1016/j.bbadis.2025.168107. PMID: 41232577.

von Stein P, von Stein J, Schindhelm F, Rudolph F, Sagmeister P, Haurand JM, Jobst J, Gröger M, Stolz L, Schulz C, Mues CA, Mustafa D, Hoerbrand IA, Sugiura A, Wolff C, Lurz P, Jahn P, Ascione G, Guthoff H, Baldus S, Rottbauer W, Gerçek M, Pfister R, Rassaf T, Weber M, Konstandin M, Möllmann H, Schofer N, Hausleiter J, Kessler M, Unsöld B, Horn P, Kister T, Rudolph V, Mahabadi AA, Granada JF, Mauri V. Small Mitral Valve Orifice Area in Mitral Valve Transcatheter Edge-to-Edge Repair: The REPAIR Study.JACC Adv. 25. Juni 2026;103014. doi: 10.1016/j.jacadv.2026.103014. PMID: 42358112.

von Stein P, Schindhelm F, Rudolph F, Sagmeister P, Haurand JM, Jobst J, Gröger M, Stolz L, Schulz C, Mues CA, Mustafa D, Hoerbrand IA, Sugiura A, Wolff C, Lurz P, von Stein J, Ascione G, Guthoff H, Baldus S, Rottbauer W, Gerçek M, Pfister R, Rassaf T, Weber M, Konstandin M, Möllmann H, Schofer N, Hausleiter J, Kessler M, Unsöld B, Horn P, Kister T, Rudolph V, Mahabadi AA, Granada JF, Mauri V. Sex-Specific Outcomes in Patients Undergoing Mitral Valve Transcatheter Edge-to-Edge Repair: The REPAIR Study.JACC Adv. Juni 2026;5(6 Pt 1):102782. doi: 10.1016/j.jacadv.2026.102782. PMID: 42132712; PMCID: PMC13309300.

Thériault S, Holdcraft JA, Sharipova D, Faucherre A, Debiec RM, Peloso GM, Al-Kassou B, Aranki S, Ashikhmina Swan E, Ballotta A, Bellino M, Björck HM, Boureau AS, Braund PS, Corriveau F, Dagenais F, Folkersen L, Forte A, Francke MD, Frigiola A, Gorbatov S, Guo D, Habchi KM, Heydarpour M, Isselbacher EM, Jopling C, Laporte F, Le Scouarnec S, Li Z, Lichtner P, Maj C, Manikpurage HD, Nelson CP, Nguyen TB, Norris RA, Ong CS, Pibarot P, Roychowdhury T, Sarubbi B, Simonet F, Sundt T, Surakka I, Tessler I, Willer CJ, Wittmann S, Yang B, Berezovets I, Doppler SA, Dreßen M, Knoll K, Puehler T, Schunkert H, Avierinos JF, Bissell MM, Bolger AP, Bossé Y, Bossone E, Brion M, Citro R, de Vincentiis C, Deeb GM, Della Corte A, Dina C, Durst R, Ensminger S, Eriksson P, Evangelista A, Franco-Cereceda A, Gilon D, Giusti B, Hetherington SL, Huggins GS, Krane M, Le Tourneau T, Limongelli G, Mathieu P, Messika-Zeitoun D, Michelena HI, Milewicz D, Muehlschlegel JD, Murdock DR, Nickenig G, Nistri S, Nöthen MM, Pluchinotta F, Prakash SK, Samani NJ, Schott JJ, Webb TR, Zaffran S, Abdelilah-Seyfried S, Eagle K, Schumacher J, Trenkwalder T, Body SC. Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.Circulation. 7. April 2026;153(14):1060–76. doi: 10.1161/CIRCULATIONAHA.125.074752. PMID: 41645906; PMCID: PMC13001617.

Small AM, Yang TY, Itoh S, Thériault S, Dufresne L, Kurosawa R, Komuro I, Matsuda K, Vy HMT, Farber-Eger EH, Shaffer LL, Boulier KM, Corey KM, Ramaker ME, Laporte F, Schott JJ, Le Scouarnec S, Singh SA, Sonawane AR, Smith HA, Rafaels N, Ghouse J, Raja AA, Ostrowski SR, Sørensen E, Mikkelsen C, Pedersen OB, Erikstrup C, Ullum H, Sveinbjornsson G, Gudbjartsson DF, Abner E, Lee J, Ganna A, Nowak-Göttl U, Finer S, Schumacher J, Maj C, Al-Kassou B, Nickenig G, Trenkwalder T, Dreβen M, Krane M, Nöthen MM, Moksnes MR, Brumpton BM, Knight S, Knowlton KU, Nadauld L, Debiec R, Musameh MD, Braund PS, Nelson CP, Czuba T, Melander O, Selvaraj MS, Koyama S, Bhukar R, Ruan Y, Ljungberg J, Damrauer SM, Levin MG, Franke A, Berger K, Ruff CT, Melloni GEM, Kamanu FK, Ito K, Do R, Loos RJF, Schunkert H, Wells QS, Shah SH, Le Tourneau T, Messika-Zeitoun D, Gignoux C, Bundgaard H, Larsson SC, Michaëlsson K, Holm H, Helgadottir A, Esko T, van Heel DA, Mathieu P, Samani NJ, Smith JG, Söderberg S, Rader DJ, Marston NA, Sabatine MS, Pasaniuc B, Cho K, Wilson PWF, O’Donnell CJ, Stefansson K, Bossé Y, Aikawa E, Engert JC, Peloso GM, Natarajan P, Thanassoulis G. Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.Nat Genet. Januar 2026;58(1):57–66. doi: 10.1038/s41588-025-02417-6. PMID: 41419686; PMCID: PMC12807872.

Schelemei P, Picard FSR, Park Y, Wollnitzke P, Nemade H, Lechner SK, Mehrkens D, Arkenberg P, Köbele AC, Wrobel J, Martinez Lagunas K, Wagner E, Guthoff H, Hof A, Cummings K, Al Zaidi M, Zimmer S, Roy J, Lindquist Liljeqvist M, Wolf D, Riffelmacher T, Ibing W, Wagenhäuser MU, Schelzig H, Levkau B, Flögel U, Gerdes N, Karimpour M, Hillmer AM, Sengle G, Megens RTA, Weber C, Orecchioni M, Baldus S, Mollenhauer M, Winkels H. Olfr2 Promotes Recruitment of Monocytes via CX3CR1 in Abdominal Aortic Aneurysm.Circ Res. 30. Januar 2026;138(3). doi: 10.1161/CIRCRESAHA.125.326591. PMID: 41473953.

Nemade H, Mehrkens D, Lottermoser HS, Yilmaz ZE, Mader J, Schelemei P, Picard FR, Geißen S, Schwab GF, Hoyer FF, Guthoff H, Hof A, Nettersheim FS, Sachinidis A, Gerdes N, Sengle G, Winkels H, Baldus S, Pasparakis M, Mollenhauer M, Adam M. Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis.Cell Death Dis. 11. Februar 2026;17(1):217. doi: 10.1038/s41419-026-08427-4. PMID: 41672970; PMCID: PMC12920694.

Mehrkens D, Dohr J, Nettersheim FS, Ballmann F, Bastigkeit J, Brückner A, Geissen S, De Vore L, Fitsch C, Diekmann C, de la Fuente-Alonso A, Schelemei P, Picard FR, Kochen M, Arkenberg P, Rappenecker A, Ahdab M, Nemade H, Narayan S, Braumann S, Kreuzberg W, Hof A, Guthoff H, Mensah BQ, Lechner S, Guala A, Evangelista A, Teixido-Tura G, Nistal JF, Campanero MR, Kaemmerer H, Wolf Z, Holdenrieder S, Groenink M, van Andel M, Mieremet A, Pfeiler S, Gerdes N, Flögel U, Zimmermann LM, Sengle G, Eich ML, Schömig-Markiefka B, Adam M, Fleischmann BK, Wenzel D, Redondo JM, de Waard V, Klinke A, Baldus S, Mollenhauer M, Winkels H. Myeloperoxidase aggravates thoracic aortic aneurysm formation in Marfan disease.Cardiovasc Res. 16. März 2026;122(2):230–44. doi: 10.1093/cvr/cvaf248. PMID: 41403006.

Guthoff H, Abdel-Waha M, Kim WK, Wienemann H, Shamekhi J, Eckel C, von der Heide I, Veulemans V, Landt M, Schewel J, Van Mieghem NM, Adrichem R, Toggweiler S, Rheude T, Macherey-Meyer S, Bleiziffer S, Al-Kassou B, Nienaber S, Wrobel J, Richter I, Möllmann H, Renker M, Charitos E, Schofer N, Zeus T, Schmidt T, von Stein P, Thiele H, Witberg G, Adam M, Baldus S, Rudolph TK, Mauri V. Sex differences in hemodynamics and outcomes after transcatheter aortic valve replacement.Clin Res Cardiol. Juli 2026;115(7):1207–17. doi: 10.1007/s00392-025-02794-2. PMID: 41264012; PMCID: PMC13249733.

Yogathasan V, Wischmann P, Solga I, Jäger L, Becher S, Cortese-Krott MM, Gerdes N, Kelm M, Jung C, Chennupati R. Divergent roles of endothelial and red blood cell nitric oxide synthase in regulating cardiovascular function during anemia.Nitric Oxide. Dezember 2025;159:1–10. doi: 10.1016/j.niox.2025.08.004. PMID: 40865872.

Wenzl FA, Wang P, Kahles F, Beck KR, Giannitsis E, Obeid S, Bruno F, Li XS, Nanchen D, Liberale L, Smolle MA, Schweiger V, Klingenberg R, Manka R, Stähli BE, Templin C, König M, Yuan J, Yildirim M, Lehrke M, von Eckardstein A, Marx N, Mach F, Räber L, Katus HA, Steinhagen-Thiessen E, Demuth I, Deanfield J, Libby P, Hazen SL, Haghikia A, Landmesser U, Bäckhed F, Lüscher TF. Gut microbiota-derived imidazole propionate predicts cardiometabolic risk in patients with coronary artery disease.Eur Heart J. 30. August 2025;ehaf661. doi: 10.1093/eurheartj/ehaf661. PMID: 40884168.

von Stein P, Stolz L, Haurand JM, Gröger M, Rudolph F, Mustafa D, Jobst J, Mues CA, Mahabadi AA, Hoerbrand IA, Schulz C, Sugiura A, von Stein J, Iliadis C, Lurz P, Gerçek M, Horn P, Kessler M, Ascione G, Rassaf T, Weber M, Schofer N, Konstandin M, Schindhelm F, Möllmann H, Unsöld B, Guthoff H, Baldus S, Rottbauer W, Rudolph V, Granada JF, Hausleiter J, Pfister R, Mauri V. Transcatheter Edge-to-Edge Repair for Atrial and Ventricular Secondary Mitral Regurgitation: Insights From the REPAIR Study.JACC Cardiovasc Interv. 25. August 2025;18(16):2020–32. doi: 10.1016/j.jcin.2025.05.031. PMID: 40560108.

von Stein P, Stolz L, Haurand JM, Gröger M, Rudolph F, Mustafa D, Jobst J, Mues CA, Mahabadi AA, Hoerbrand IA, Schulz C, Sugiura A, Ruf T, Lurz P, Gerçek M, Horn P, Kessler M, Rassaf T, Weber M, Kister T, Schofer N, Konstandin M, Schindhelm F, Möllmann H, Unsöld B, Baldus S, Rottbauer W, Rudolph V, Hausleiter J, Pfister R, Mauri V. Outcomes and Impact of Device Iterations in Mitral Valve Transcatheter Edge-to-Edge Repair: The REPAIR Study.JACC Cardiovasc Interv. 10. März 2025;18(5):573–86. doi: 10.1016/j.jcin.2024.11.016. PMID: 39745410.

von Stein P, Hausleiter J, Horn P, Kessler M, Rudolph V, Unsöld B, Möllmann H, Mahabadi AA, Kister T, Mauri V. Transcatheter Edge-to-Edge Repair in Secondary Mitral Regurgitation: Mind the Gap Between Guidelines and COAPT Criteria.JACC Cardiovasc Interv. 8. Dezember 2025;18(23):2967–9. doi: 10.1016/j.jcin.2025.09.036. PMID: 41137833.

von Stein P, Hausleiter J, Horn P, Kessler M, Rudolph V, Unsöld B, Lurz P, Weber M, Schofer N, Konstandin MH, Granada JF, Möllmann H, Mahabadi AA, Kister T, Mauri V. Pulmonary Artery Systolic Pressure Trajectories After Transcatheter Edge-to-Edge Repair in Atrial and Ventricular Secondary Mitral Regurgitation.Circ Cardiovasc Interv. Dezember 2025;18(12). doi: 10.1161/CIRCINTERVENTIONS.125.016067. PMID: 41241823.

Trenkwalder T, Maj C, Al-Kassou B, Debiec R, Doppler SA, Musameh MD, Nelson CP, Dasmeh P, Grover S, Knoll K, Naamanka J, Mordi IR, Braund PS, Dreßen M, Lahm H, Wirth F, Baldus S, Kelm M, von Scheidt M, Krefting J, Ellinghaus D, Small AM, Peloso GM, Natarajan P, Thanassoulis G, Engert JC, Dufresne L, Franke A, Görg S, Laudes M, Nowak-Göttl U, Vaht M, Metspalu A, Stoll M, Berger K, Pellegrini C, Kastrati A, Hengstenberg C, Lang CC, Kessler T, Hovatta I, Nickenig G, Nöthen MM, Krane M, Schunkert H, Samani NJ, Schumacher J, Kals M, Reigo A, Teder-Laving M, Gehlen J, Webb TR, Giel AS, Koebbe LL, Feirer N, Billmann M, Srinivasan S, Zimmer S, Palmer CNA, Li L, Yang C, Borisov O, Adam M, Veulemans V, Joner M, Xhepa E. Distinct Genetic Risk Profile in Aortic Stenosis Compared With Coronary Artery Disease.JAMA Cardiol. 1. Februar 2025;10(2):145–54. doi: 10.1001/jamacardio.2024.3738. PMID: 39504041; PMCID: PMC11541746.

Stei M, Arkenberg P, Uebing T, Mazrekaj A, Mulorz J, Mehrkens D, Ahdab M, Barnowski P, Sengle G, Adam M, Lohner V, Hoerr V, Nahardani A, Schubert-Quecke C, Mewes B, Lindemeyer J, Grüll H, Busch A, Zimmer S, Winkels H, Schelzig H, Kelm M, Nickenig G, Baldus S, Wagenhäuser MU, Mollenhauer M. An improved porcine model of infrarenal abdominal aortic aneurysm.Sci Rep. 17. Dezember 2025;15(1):44059. doi: 10.1038/s41598-025-31690-y. PMID: 41408131; PMCID: PMC12714784.

Spanou CES, Yang C, Godwin ARF, Morosky S, Anbalagan A, Lütke S, Mörgelin M, Marcous F, Aziz U, Wohl AP, Jabeen I, Koch M, Jowitt TA, Roman BL, Tarakanova A, Baldock C, Sengle G. Prodomain processing controls BMP-10 bioactivity and targeting to fibrillin-1 in latent conformation.FASEB J. 15. Februar 2025;39(3). doi: 10.1096/fj.202401694R. PMID: 39921464; PMCID: PMC11806408.

Solga I, Şahin A, Yogathasan V, Hofer L, Celik FG, El Rai A, Hosen MR, Wischmann P, Becher S, Polzin A, Gerdes N, Jung C, Kelm M, Chennupati R. Acute blood loss anemia aggravates endothelial dysfunction after acute myocardial infarction.Front Cardiovasc Med. 2025;12:1635293. doi: 10.3389/fcvm.2025.1635293. PMID: 41158731; PMCID: PMC12554764.

Rudolph F, Geyer M, Baldus S, De Luca VM, Doenst T, Pfister R, Gummert J, Kessler M, Boekstegers P, Lubos E, Schröder J, Thiele H, Walther T, Kelm M, Hausleiter J, Eitel I, Fischer-Rasokat U, Bufe A, Schmeisser A, Ince H, Lurz P, von Bardeleben RS, Hagl C, Noack T, Reith S, Beucher H, Reichenspurner H, Rottbauer W, Schulze PC, Müller W, Frank J, Michalik C, Hellmich M, Wahlers T, Rudolph V, Iliadis C. Transcatheter Repair Versus Surgery for Atrial Versus Ventricular Functional Mitral Regurgitation: A Post Hoc Analysis of the MATTERHORN Trial.Circulation. 11. Februar 2025;151(6):418–20. doi: 10.1161/CIRCULATIONAHA.124.072648. PMID: 39475706.

Mustafa D, von Stein J, Stolz L, Haurand JM, Gröger M, Rudolph F, Jobst J, Mues CA, Mahabadi AA, Hoerbrand IA, Schulz C, Sugiura A, Lurz P, Kister T, Sagmeister P, Wolff C, Gerçek M, Horn P, Kessler M, Ascione G, Rassaf T, Weber M, Schofer N, Konstandin MH, Schindhelm F, Möllmann H, Unsöld B, Guthoff H, Baldus S, Rottbauer W, Rudolph V, Granada JF, Hausleiter J, Pfister R, Mauri V, von Stein P. Relation of Residual Mitral Regurgitation and Gradient Following Mitral Valve Transcatheter Edge-to-Edge Repair.Circ Cardiovasc Interv. November 2025;18(11). doi: 10.1161/CIRCINTERVENTIONS.125.015845. PMID: 41150378.

Mourikis P, Benkhoff M, Wildeis L, Barcik M, Helten C, Coman C, Solari FA, Krahn D, Dannenberg L, Ahlbrecht S, Zikeli D, Utz A, Trojovsky K, Richter H, Al Kassis G, M’Pembele R, Zako S, Huckenbeck T, Bauer S, Schmitz D, Pfeiler S, Gerdes N, Dücker C, Pircher J, Zhe Z, Thienel M, Ul Ain Q, Keul P, Kirkby N, Sohn D, Budach W, Hohlfeld T, Schrör K, Levkau B, Zeus T, Verhelst SHL, Ahrends R, Sickmann A, Mitchell J, Mora S, Manson JE, Bhatt DL, Landmesser U, Massberg S, Kelm M, Petzold T, Polzin A. Icosapent ethyl reduces arterial thrombosis by inhibition of cyclooxygenase-1-induced platelet reactivity.Sci Transl Med. 21. Mai 2025;17(799). doi: 10.1126/scitranslmed.ado0610. PMID: 40397711.

Moellmann J, Glandien K, Klinkhammer BM, Wollenhaupt J, Noels H, Jankowski J, Lebherz C, Boor P, Lehrke M, Marx N. Development of a Mouse Model of Uremic Cardiomyopathy: Investigating the Impact of Chronic Kidney Disease on Cardiac Function and Signaling Pathway.FASEB J. 31. Mai 2025;39(10). doi: 10.1096/fj.202500281R. PMID: 40386987; PMCID: PMC12086955.

Marx-Schütt K, Cherney DZI, Jankowski J, Matsushita K, Nardone M, Marx N. Cardiovascular disease in chronic kidney disease.Eur Heart J. 16. Juni 2025;46(23):2148–60. doi: 10.1093/eurheartj/ehaf167. PMID: 40196891; PMCID: PMC12167664.

Kurt B, Reugels M, Schneider KM, Spiesshoefer J, Milzi A, Gombert A, Fordyce CB, Wenzl FA, Pagidipati NJ, Rocha V, Fudim M, Sharma A, Lehrke M, Shimokawa H, Liuzzo G, Tokgozoglu L, Crea F, Lüscher TF, Libby P, Ridker PM, Marx N, Schneider CV, Kahles F. C-reactive protein and cardiovascular risk in the general population.Eur Heart J. 11. Dezember 2025;47(15):1799–810. doi: 10.1093/eurheartj/ehaf937. PMID: 41378999; PMCID: PMC13101082.

Kurt B, Rau M, Hartmann O, Bergmann A, Reugels M, Just S, Wenzl FA, Moellmann J, Spießhöfer J, Milzi A, Kneizeh K, Thiele K, Hohl M, Selejan SR, van der Vorst EPC, Dahl E, Schröder J, Lüscher TF, Marx N, Lehrke M, Kahles F. Adjustment of the SMART risk score by bioactive adrenomedullin enables a more accurate prediction of mortality in patients with ASCVD.Atherosclerosis. Juli 2025;406:120220. doi: 10.1016/j.atherosclerosis.2025.120220. PMID: 40449381.

Jung C, Lang A, Duse DA, Bruno RR, Pöss J, Wolff G, Ceglarek U, Zeymer U, Fuernau G, Zweck E, Desch S, Freund A, Isermann B, Pfeiler S, Wernly B, Kelm M, Thiele H, Gerdes N. Plasma Proteome Analysis Identifies Vascular Endothelial Growth Factor Receptor 1 as a Prognostic Biomarker in Cardiogenic Shock.Circ Heart Fail. Dezember 2025;18(12). doi: 10.1161/CIRCHEARTFAILURE.125.012890. PMID: 41031405.

Humbert M, McLaughlin VV, Badesch DB, Ghofrani HA, Gibbs JSR, Gomberg-Maitland M, Preston IR, Souza R, Waxman AB, Moles VM, Savale L, Vizza CD, Rosenkranz S, Shi Y, Miller B, Mackenzie HS, Kim SS, Loureiro MJ, Patel MJ, Koglin J, Cornell AG, Hoeper MM. Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death.N Engl J Med. 29. Mai 2025;392(20):1987–2000. doi: 10.1056/NEJMoa2415160. PMID: 40167274.

Heyn J, Gorgels A, Hense N, Gombert A, Buhl EM, Stark L, Vondenhoff S, Simon J, Noels H, Marx N, Goettsch C. GRP75 inhibition attenuates arterial calcification.Atherosclerosis. Oktober 2025;409:119243. doi: 10.1016/j.atherosclerosis.2025.119243. PMID: 40410081.

Guthoff H, Abdel-Wahab M, Kim WK, Shamekhi J, Möllmann H, Van Mieghem NM, Toggweiler S, Rheude T, Zeus T, Rudolph TK, Mauri V. Clinical Impact of Balloon-Expandable vs Self-Expanding TAVR in Small Aortic Annuli.JACC Cardiovasc Interv. 23. Juni 2025;18(12):1611–3. doi: 10.1016/j.jcin.2025.03.020. PMID: 40338787.

de Souza RB, Cassiano LL, Barnowski P, Ventura S, Turato WM, Nascimento SCR, Mignanelli GL, Caldeira W, da Fonseca Martins AMCRP, de Carvalho Luposeli F, Laurindo FRM, Reinhardt DP, Sengle G, Koh IHJ, Meek KM, Lewis PN. Exploring thoracic aorta ECM alterations in Marfan syndrome: insights into aorta wall structure.Sci Rep. 22. Juli 2025;15(1):26665. doi: 10.1038/s41598-025-09665-w. PMID: 40695874; PMCID: PMC12284111.

Casagrande V, Panarello L, Lepri A, Quatrana A, Internò C, Antonetti L, Bonanno E, Cicalini I, Pieragostino D, Gorgels A, De Laurenzi V, Goettsch C, Cardellini M, Federici M, Menghini R. Effect of 3-hydroxyisobutyrate in vivo administration on cardiometabolic disease in ApoE-/- mouse model.Pharmacol Res. Oktober 2025;220:107943. doi: 10.1016/j.phrs.2025.107943. PMID: 40930330.

Bruenger CMH, Oeffner F, Koebbe LL, Zimmer S, Veulemans V, Adam M, Bigge J, Heilmann-Heimbach S, Kelm M, Baldus S, Nöthen MM, Nickenig G, Maj C, Al-Kassou B, Schumacher J. Implications of monogenic bicuspid aortic valve (BAV) forms among sporadic BAV patients.Eur J Hum Genet. September 2025;33(9):1203–6. doi: 10.1038/s41431-025-01909-7. PMID: 40646242; PMCID: PMC12402177.

Berger M, Reugels M, Heinzmann A, Lysaja K, Rizk M, Kern JS, Wolf M, Wolfart S, Jankowski V, Jankowski J, Marx N, Marx-Schütt K. Association of Complement Factor D with Cardiovascular Mortality and Clot Lysis in CKD.J Am Soc Nephrol. 1. Dezember 2025;36(12):2469–72. doi: 10.1681/ASN.0000000870. PMID: 40844849; PMCID: PMC12677817.

Benkhoff M, Barcik M, Mourikis P, Dahlmanns J, Kahmann P, Wollnitzke P, Hering M, Huckenbeck T, Hoppe J, Semleit N, Deister-Jonas J, Zako S, Seel J, Coman C, Barth M, Cramer M, Helten C, Wildeis L, Hu H, Al-Kassis G, Metzen D, Hesse J, Weber J, Dannenberg L, Akhyari P, Lichtenberg A, Quast C, Gerdes N, Zeus T, Borst O, Kelm M, Petzold T, Ahrends R, Levkau B, Polzin A. Targeting Sphingosine-1-Phosphate Signaling to Prevent the Progression of Aortic Valve Disease.Circulation. 28. Januar 2025;151(4):333–47. doi: 10.1161/CIRCULATIONAHA.123.067270. PMID: 39429140.

Zierden M, Berghausen EM, Gnatzy-Feik L, Millarg C, Picard FSR, Kiljan M, Geißen S, Polykratis A, Zimmermann L, Nies RJ, Pasparakis M, Baldus S, Valasarajan C, Pullamsetti SS, Winkels H, Vantler M, Rosenkranz S. Hematopoietic PI3Kδ deficiency aggravates murine atherosclerosis through impairment of Tregs.JCI Insight. 22. November 2024;9(22). doi: 10.1172/jci.insight.155626. PMID: 39378110; PMCID: PMC11601942.

von Stein P, Wienemann H, von Stein J, Sugiura A, Tanaka T, Kavsur R, Öztürk C, Weber M, Haurand JM, Horn P, Kister T, Mahabadi AA, Boeder N, Ruf T, Gerçek M, Mues C, Grothusen C, Novotny J, Weckbach L, Guthoff H, Rudolph F, Polzin A, Baldus S, Rassaf T, Thiele H, Möllmann H, Kelm M, Rudolph V, von Bardeleben RS, Nef H, Luedike P, Lurz P, Hausleiter J, Pfister R, Mauri V. Early Outcomes of Two Large Mitral Valve Transcatheter Edge-to-Edge Repair Devices-A Propensity Score Matched Multicenter Comparison.J Clin Med. 17. Juli 2024;13(14). doi: 10.3390/jcm13144187. PMID: 39064227; PMCID: PMC11278441.

Schelemei P, Wagner E, Picard FSR, Winkels H. Macrophage mediators and mechanisms in cardiovascular disease.FASEB J. Februar 2024;38(2). doi: 10.1096/fj.202302001R. PMID: 38275140.

Quast C, Bönner F, Polzin A, Veulemans V, Chennupati R, Gyamfi Poku I, Pfeiler S, Kramser N, Nankinova M, Staub N, Zweck E, Jokiel J, Keyser F, Hoffe J, Witkowski S, Becker K, Leuders P, Zako S, Erkens R, Jung C, Flögel U, Wang T, Neidlin M, Steinseifer U, Niepmann ST, Zimmer S, Gerdes N, Cortese-Krott MM, Feelisch M, Zeus T, Kelm M. Aortic Valve Stenosis Causes Accumulation of Extracellular Hemoglobin and Systemic Endothelial Dysfunction.Circulation. 17. September 2024;150(12):952–65. doi: 10.1161/CIRCULATIONAHA.123.064747. PMID: 38836358.

Moellmann J, Krueger K, Wong DWL, Klinkhammer BM, Buhl EM, Dehairs J, Swinnen JV, Noels H, Jankowski J, Lebherz C, Boor P, Marx N, Lehrke M. 2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function.Biochim Biophys Acta Mol Basis Dis. Januar 2024;1870(1):166825. doi: 10.1016/j.bbadis.2023.166825. PMID: 37536502.

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